Sirolimus-induced lymphoedema

Sirolimus-induced lymphoedema.

Sirolimus is an inhibitor of the mammalian target of rapamycin (mTOR), used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders. We report a case of lymphoedema, a rare complication of sirolimus, and discuss the mechanism of drug action, the adverse effects and the challenges of treating a kidney transplant recipient with this complication in a r...

Sirolimus-induced inflammatory lymphoedema of the breast resolved after switching to cyclosporine.

Sirolimus induced granulomatous interstitial pneumonitis

OBJECTIVES Report a case of sirolimus induced granulomatous pneumonitis. BACKGROUND Sirolimus is used in clinical transplantation as an immunosuppressive agent. Pulmonary toxicity does occur, but only a few cases of sirolimus associated granulomatous interstitial pneumonitis have been reported. METHODS Case report and literature review. RESULTS This 53-year-old woman with ESRD from polycy...

Phenytoin-induced reduction in sirolimus levels.

Sirolimus is used primarily to prevent rejection of solid organ grafts. This drug is a substrate for hepatic and intestinal cytochrome P450 3A4 isozyme (CYP3A4) and P-glycoprotein and is therefore susceptible to many drug interactions. Phenytoin is a strong inducer of CYP2C9, CYP2C19, and CYP3A4, so it may increase the hepatic metabolism of many medications. A case of phenytoin-induced decline ...

Lymphoedema-distichiasis syndrome.

To cite: Marques NS, Miranda A, Barros S, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2015-213651 DESCRIPTION A 29-year-old woman with a history of renal cysts, hypertension and lymphoedema-distichiasis syndrome, was referred to ophthalmology, with bilateral blurred vision, hyperaemia and ocular pain, developed over months. The patient had no positive ...